Mutations in the HA and M2 proteins.

1Determined by HA2 numbering (+16 from aminoacid one in coding sequence, [39], [40].2Amantadine sensitivity given by mutation in position 31 of M2 protein. S = sensitivity, N = resistance.3Antigenic sites B and E are conformational epitopes.4Changes of interest are shown in bold and italics.1. 采用血凝素2（HA2）编号规则（相对于编码序列的第1位氨基酸偏移+16，引用文献[39]、[40]）。 2. 金刚烷胺敏感性由M2蛋白第31位氨基酸的突变决定，其中S代表敏感，N代表耐药。 3. 抗原位点B与E属于构象表位。 4. 本研究关注的变异以粗斜体标注。