Sotrovimab Resistance Genomic Profiling Across 4.68 Million SARS-CoV-2 Genomes

This dataset reports the prevalence of three Spike amino acid substitutions G339D, S371F, and N460K across 4,678,626 SARS-CoV-2 genomes (out of 9,356,279 total) from global public repositories (2020 - 2025). These mutations are associated with reduced susceptibility to the monoclonal antibody sotrovimab. For each genome containing ≥1 of these mutations, the dataset includes: Genome identifier (seq_id)List of detected mutations (G339D, S371F, N460K, or combinations)Whole-genome mutation burden (SNP count) and frequencySpike protein reference and query amino acid sequencesGenomic coordinates of the Spike region (Wuhan-Hu-1: nt 21563–25384)Spike and whole-genome lengths Data was derived from a high-quality alignment of 9.35M genomes (QC ≥28,000 nt) referenced to Wuhan-Hu-1 (NC_045512.2) locally. Files are provided as 4,679 tab-separated chunks (1,000 records each), enabling scalable analysis of sotrovimab-relevant mutational signals at pandemic scale. Sotrovimab Resistance Signal Profiling by Tahir Bhatti [e-mail]