Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors Descriptor: 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... Authors: Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Tosteb, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W. Deposit date: 2013-04-27 Release date: 2013-05-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013基于结构发现新型含酰胺类烟酰胺磷酸核糖转移酶（Nicotinamide Phosphoribosyltransferase, Nampt）抑制剂 描述符：1,2-乙二醇、N-{4-[(3,5-二氟苯基)磺酰基]苄基}咪唑并[1,2-a]吡啶-6-甲酰胺、烟酰胺磷酸核糖转移酶（Nampt）等 作者：Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Tosteb, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W 提交日期：2013-04-27 发布日期：2013-05-08 最后修改日期：2024-02-28 研究方法：X射线衍射（1.6 Å） 引用文献：基于结构鉴定脲类新型烟酰胺磷酸核糖转移酶（Nampt）抑制剂，《药物化学杂志》（J. Med. Chem.），56卷，2013年