Structure of Compound 5 bound to the CHK1 10-point mutant

Structure of Compound 5 bound to the CHK1 10-point mutant Descriptor: (1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide, Serine/threonine-protein kinase Chk1 Authors: Palte, R.L. Deposit date: 2023-04-17 Release date: 2023-11-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.877 Å) Cite: Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023