Structure of MBP-Mcl-1 in complex with MIK665

Structure of MBP-Mcl-1 in complex with MIK665 Descriptor: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Judge, R.A, Judd, A.S, Souers, A.J. Deposit date: 2022-09-22 Release date: 2023-11-08 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023与MIK665结合的MBP-Mcl-1复合物结构 描述：(2R)-2-[5-[3-氯-2-甲基-4-[2-(4-甲基哌嗪-1-基)乙氧基]苯基]-6-(4-氟苯基)噻吩并[2,3-d]嘧啶-4-基]氧基-3-[2-[[2-(2-甲氧基苯基)嘧啶-4-基]甲氧基]苯基]丙酸、周质麦芽糖/麦芽糖糊精结合蛋白（Maltose/maltodextrin-binding periplasmic protein）、诱导髓系白血病细胞分化蛋白Mcl-1（Induced myeloid leukemia cell differentiation protein Mcl-1）、α-D-吡喃葡萄糖-(1→4)-α-D-吡喃葡萄糖。作者：Judge R.A.、Judd A.S.、Souers A.J.。存档日期：2022年9月22日；发布日期：2023年11月8日；最后修改日期：2026年3月4日。检测方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.55埃）。引用文献：选择性MCL-1抑制剂ABBV-467在肿瘤模型中具有疗效，但会导致患者心肌肌钙蛋白水平升高。《Commun Med (Lond)》，2023年，第3卷。