Gene expression changes of potassium bromate-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with potassium bromate, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在开发一种基于经致癌物染毒大鼠基因表达谱（gene expression profile）的短期高精度肾脏致癌性预测方法。我们以溴酸钾（potassium bromate）对雄性SD大鼠开展28天重复剂量染毒实验，并采用定制化基因芯片（custom microarrays）分析了肾皮质的基因表达谱。