Gene expression changes of o-nitroanisole-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with o-nitroanisole, and the gene expression profiles of renal cortex were analyzed using custom microarrays. Experimental design is the two group (control group vs. o-nitroanisole treated group). Three biological replicates were performed for each group.