An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation

Mendeley Data2026-04-09 收录

肝胆类器官构建

细胞外基质调控

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BulkRNA-seq analyzed data, proteomics analyzed data, raw Western blot images, Image analysis macro and plotted data.

XDA16021307+皮肤类器官构建

干细胞研究

肝胆类器官构建

本研究通过添加不同通路抑制剂，探讨特定代谢途径对皮肤干细胞增殖和体外分化的影响。通过对比基质细胞是否参与的培养条件，证明与基质细胞共培养可以建立稳定的多层皮肤样器官结构。最后，建立了由人类胚胎干细胞衍生的多种皮肤细胞组成的类皮肤器官。研究中，通过形态学观察、HE染色和荧光染色分析细胞组成。

干细胞与再生医学数据中心2023-05-02 更新190

RNA-sequencing of multicellular human liver organoids derived from 3 different iPS cells. RNA-sequencing of multicellular human liver organoids derived from 3 different iPS cells

肝胆类器官构建

转录组学分析

By taking advantage of the foregut generation method, we initially differentiated iPSCs to foregut spheroids through definitive endoderm specification as described. The foregut spheroids were embedded

NIAID Data Ecosystem30

1a,25-Dihydroxyvitamin D3 Regulates Packaging of microRNAs within Extracellular Matrix Vesicles and Their Release in the Matrix

骨生物学

细胞外基质调控

Growth plate chondrocytes are regulated by numerous factors and hormones as they mature during endochondral bone formation. Chondrocytes in the growth plate's growth zone (GC cells) produce and export

NIAID Data Ecosystem10

Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9

血管内皮细胞力学

细胞外基质调控

Endothelial proliferation, which is an important process in vascular homeostasis, can be regulated by the extracellular microenvironment. In this study we demonstrated that proliferation of endothelia

NIAID Data Ecosystem40

The zingerone analog, acetyl zingerone, bolsters matrisome synthesis, inhibits MMPs, and represses IL-17A target gene expression [Experiment 1]

皮肤老化

细胞外基质调控

Zingerone (Z) is a phenolic alkanone derived from natural sources with anti-inflammatory and antioxidant effects. Acetyl zingerone (AZ) is a newly designed molecule that shares structural features wit

NIAID Data Ecosystem20

An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation

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