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资源简介：
HDACi improve Cas9 and Cas9-mediated base editors
应用场景：
创建时间：
2020-11-09
相关数据集
Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo
In this study we compared the gene expression of mice that had received the rAAV-GR-Cypor scgRNA and rAAV-spCas9 with and without APAP selection. APAP selected mice were also compared to mice which h
NIAID Data Ecosystem60
Homo sapiens Raw sequence reads. Homo sapiens
evaluate the affection of the f1 G8P at endogenous gene by A3A or BE3 in HEK 293T and U2OS cells, and applied G8P to promote the precision of correcting the Marfan syndrome pathogenic FBN1 mutation by
NIAID Data Ecosystem20
Mutation-specific reporter for optimization and enrichment of prime editing. Mutation-specific reporter for optimization and enrichment of prime editing
Prime editing is a versatile genome-editing technique that shows great promise for the generation and repair of patient mutations. However, some genomic sites are difficult to edit and optimal design
NIAID Data Ecosystem20
Homo sapiens Raw sequence reads
Amplicon sequencing data relating to the manuscript: "Dual inhibition of DNA-PK and Pol(theta) boosts precision of diverse prime editing systems".
NIAID Data Ecosystem20
Repair-seq screens for modulators of prime editing outcomes
Repair-seq screens measuring the effect of gene knockdown on the sequence outcomes produced by prime editors.
NIAID Data Ecosystem20
