The NuA4/TIP60 acetyltransferase complex is a key regulator of genome expression and stability. Here, we identified MBTD1 as a new stable subunit of the complex and gleaned intriguing insights into TI

NIAID Data Ecosystem20

Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60. Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60

DNA损伤修复

转录组分析

The goal of the study was to gain a comprehensive understanding of the cellular and metabolic responses to chronic genotoxic stress. We analyzed global changes in the transcriptome of xpf-1 worms in m

NIAID Data Ecosystem30

VSGseq of WT and rad50 mutant parasites following induction of a double strand break

DNA损伤修复

抗原变异

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigeni

NIAID Data Ecosystem20

Homo sapiens Raw sequence reads

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