Additional file 4 of Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway
Osteoporosis (OP) is a systemic bone disease associated with aging and imbalance in bone metabolism. In this study, the osteoprotective activity of Chinese dwarf cherry (Cerasus humilis) polyphenol ex
Background A decrease of bone mass is a major risk factor for fracture. Several natural products have traditionally been used as herbal medicines to prevent and/or treat bone disorders including osteo
To investigate the role of eosinophils on osteoclast differentiation from bone marrow-derived monocytes (BMMs), BMMs were cultivated in the presence or absence of eosinophils and eosinophil supernatan
hMSC-C = control hMSC; hMSC-OP = osteoporotic hMSC; hMSC-old = hMSC of non-osteoporotic, elderly donors; hMSC-senescent = long term-cultivated hMSC in the state of replicative senescence; standard dev
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cy