The results of gene-gene interaction analysis for top-10 SNPs (P<0.05).

ars1910047 (TBX3), rs1049970 (CDH5), rs10515978 (LMAN1), rs32588 (PPARGC1B) and rs4855881 (APEH);bMean and stand deviation of the rate of FEV1 decline (ml/month);cCoefficient, stand error, P value were acquired from linear regression model adjusted for height, age and FEV1 at baseline, and average log transformed endotoxin level.dP value for gene-gene interaction.eFDR q-value calculated based on all pair-wise (45 pairs) P values of top-10 SNPs.