Selected compounds which alter insulin secretion in acute (hours) and chronic (days) exposure scenario's.

Reported effects on basal (BIS) and glucose stimulated (GSIS) insulin secretion, and the primary targets via which the compounds exert their effects are given, together with the expected control function (positive (+), negative (−), no effect ( = )). Results from all types of in vitro beta-cell systems and species were considered. The most commonly used concentrations (“standard concentrations”), the higher concentrations selected and abbreviations used in this paper (between brackets), are also provided.