BackgroundBacillus subtilis is a probiotic strain that is widely used as a feed supplement for ruminants. In this study, one B. subtilis strain isolated from the ruminal fluid of Holstein dairy cows w

NIAID Data Ecosystem70

Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure

局灶节段性肾小球硬化症

mTORC1信号通路

Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubula

NIAID Data Ecosystem40

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

糖尿病研究

mTORC1信号通路

BackgroundPalmitate is a potent inducer of endoplasmic reticulum (ER) stress in β-cells. In type 2 diabetes, glucose amplifies fatty-acid toxicity for pancreatic β-cells, leading to β-cell dysfunction

NIAID Data Ecosystem70

JZL184 inhibited KCl-induced insulin secretion.

胰岛素分泌调节

细胞药理学实验

Insulin secretion from batch incubations of (A) INS-1 cells and (B) dissociated rat islets (n = 3 independent experiments for both A and B). Error bars represent S.E. (*, p

Figshare2016-03-16 更新70

Table S1 - Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

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