An RORgt Inverse agonist for treatment of Psoriasis

An RORgt Inverse agonist for treatment of Psoriasis Descriptor: (5P)-5-[2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[(2S)-2-methylpyrrolidine-1-carbonyl]-1,3-thiazole-2-carboxamide, Nuclear receptor ROR-gamma Authors: Spurlino, J.C, Milligan, C. Deposit date: 2025-02-11 Release date: 2025-04-30 Last modified: 2025-05-07 Method: X-RAY DIFFRACTION (1.637 Å) Cite: Identification of JNJ-61803534, a ROR gamma t Inverse Agonist for the Treatment of Psoriasis. J.Med.Chem., 68, 2025