In order to assess in vivo SHM and clonal expansion among engineered B cells, we used a synonymously re-coded 3BNC117 allele.Cells were engineered as described in Nahmad et al. 2020.

NIAID Data Ecosystem40

Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma

淋巴瘤基因组学

体细胞超突变

The processes of somatic hypermutation (SHM) and class switch recombination introduced by activation-induced cytosine deaminase (AICDA) at the Immunoglobulin (Ig) loci are key steps for creating a poo

Figshare2016-01-19 更新20

The IgH EÂµ-matrix attachment regions optimize IgH somatic hypermutation induced by error-prone repair

体细胞超突变

DNA易错修复机制

Two scaffold/matrix attachment regions (5'- and 3'-MARsEÂµ) flank the intronic core enhancer (cEÂµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, th

NIAID Data Ecosystem70

Table_1_Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes.xlsx

DNAG-四链体结构预测

体细胞超突变

Activation-induced deaminase (AID) is a key enzyme involved in antibody diversification by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) of the Immunoglobulin (Ig) loci.

NIAID Data Ecosystem20

AID-CRY UPD-SEQ

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