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Synthesis of 2‑Arylbenzothiazole and 2‑Arylthiazole Derivatives via a Ru-Catalyzed meta-Selective C–H Nitration Reaction

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Figshare2019-07-19 更新2026-04-29 收录
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A Ru-catalyzed meta-selective C–H nitration of 2-arylbenzothiazoles and 2-arylthiazoles has been developed. A wide range of functional groups are tolerated, providing the meta-nitrated products in good to excellent yields using Cu­(NO3)2·3H2O as the nitro source. The nitration could be carried out on a gram scale and used for the synthesis of promising therapeutic leads for human African trypanosomiasis.

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2019-07-19
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