Synthesis of Lactams via Copper-Catalyzed Intramolecular Vinylation of Amides
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Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N‘-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.
创建时间：
2005-05-12
