2-氯烟酸产品无机盐分析数据

2-氯烟酸是一种非常重要的医药和农药中间体，作为医药中间体用于合成烟甲灭酸、烟氟灭酸等，作为农药中间体用于合成烟嘧磺隆、吡氟草胺等。在2-氯烟酸制备过程中采用氢氧化钠水解2-氯烟腈再用盐酸酸析合成，该过程中会产生氯化钠等无机盐残留在产品中，从而影响产品的品质。通过对2-氯烟酸产品中无机盐的分析，即是评价化合物含量和纯度的重要指标之一，也为下游产品的质量控制提供保障。企业生产的2-氯烟酸产品，取样后采用AgNO3标准溶液进行电位滴定测试产品中的无机盐含量，该无机盐成分主要为氯化钠，滴定过程反应方程式为：AgNO3+NaCl=AgCl↓+NaNO3。1、仪器和测试条件：测试仪器电位滴定仪器，取样并使用分析天平精确称重，配置1：1硝酸水溶液，配置一定浓度的AgNO3标准溶液，记录样品质量m和AgNO3标准溶液浓度C。2、数据采集：将样品置于100mL烧杯中，加入50mL水溶解，滴加5滴1：1硝酸水溶液，再采用AgNO3标准溶液进行滴定，观察电极电位的突跃，当二级微分为0时，即为滴定终点，记录AgNO3标准溶液滴定消耗体积V。3、数据计算：采用公式计算无机盐含量X，X=C*V*M*0.001/m*100%，其中C为AgNO3标准溶液浓度，V为AgNO3标准溶液滴定消耗体积，M为氯化钠的分子量58.44g/mol，m为样品质量。4、数据评价：无机盐含量符合客户要求的标准。2-Chloronicotinic acid is a critically important pharmaceutical and agrochemical intermediate. As a pharmaceutical intermediate, it is used for the synthesis of nicomfenamic acid, nicoflumic acid, and other related compounds; as an agrochemical intermediate, it is employed in the synthesis of nicosulfuron, diflufenican, and other agrochemical products. 2-Chloronicotinic acid is typically synthesized via hydrolysis of 2-chloronicotinonitrile with sodium hydroxide, followed by acidification with hydrochloric acid. During this synthetic process, inorganic salts such as sodium chloride may remain in the final product, which adversely affects the product's quality. Analysis of inorganic salts in 2-chloronicotinic acid products serves as one of the key indicators for evaluating compound content and purity, and also provides assurance for quality control of downstream products. For 2-chloronicotinic acid products manufactured by enterprises, the inorganic salt content (mainly sodium chloride) is tested via potentiometric titration using AgNO3 standard solution after sampling. The reaction equation during the titration procedure is: AgNO3 + NaCl = AgCl↓ + NaNO3. 1. Instruments and Test Conditions: The test instrument is a potentiometric titrator. First, accurately weigh the sample using an analytical balance, prepare a 1:1 nitric acid aqueous solution, and prepare an AgNO3 standard solution with a predetermined concentration. Record the sample mass m and the concentration C of the AgNO3 standard solution. 2. Data Collection: Place the sample into a 100 mL beaker, add 50 mL of water to dissolve the sample, add 5 drops of the 1:1 nitric acid aqueous solution, then perform titration with the AgNO3 standard solution. Observe the abrupt change in the electrode potential. The titration end point is reached when the second derivative of the potential is 0. Record the volume V of the AgNO3 standard solution consumed during titration. 3. Data Calculation: Calculate the inorganic salt content X using the following formula: X = (C * V * M * 0.001 / m) * 100%, where C is the concentration of the AgNO3 standard solution, V is the volume of the AgNO3 standard solution consumed during titration, M is the molecular weight of sodium chloride (58.44 g/mol), and m is the mass of the sample. 4. Data Evaluation: The inorganic salt content meets the customer's required standards.

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该数据集记录了2-氯烟酸产品中无机盐含量的分析数据，包括样品名称、检测仪器、样品质量、AgNO3标准溶液浓度、滴定消耗体积等关键信息，主要用于评估产品中氯化钠等无机盐的含量，确保产品质量。数据规模为272条，每日更新，适用于医药和农药中间体的质量控制。