Table4_Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study.DOCX

Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development.胃癌在中国所有恶性肿瘤中发病率位列第二，仅次于肺癌，同时亦是癌症相关死亡的主要诱因之一，因此仍是严重威胁人类健康的重大疾病。目前胃癌的发病机制尚未完全阐明，且早期检测缺乏兼具高灵敏度与高特异性的检测手段。近数十年来，学界已陆续鉴定出多个胃癌相关基因。为筛选上述胃癌相关基因中的潜在胃癌易感变异位点，本研究开展了一项病例对照研究：共纳入7个胃癌相关基因上的29个标签单核苷酸多态性（tagSNP）位点，招募228名胃癌患者与299名健康对照个体。研究发现，EFNA1基因rs4971066多态性的基因型频率在胃癌患者与健康对照间存在显著差异；结果显示，ephrin-A1基因的tagSNP rs4971066 GT/TT基因型可显著降低胃癌的发病易感性。