Supplementary Material for: Association between Atrial Fibrillation and Aortic Aneurysms: A Population-Based Cohort Study

Objective: Atrial fibrillation (AF) is the most common form of sustained arrhythmia. Several molecular pathways associated with the pathogenesis of AF also participate in the initiation and progression of aortic aneurysm (AA). In this study, we aimed to evaluate potential associations between AA and AF. Patients and Methods: The data for this nationwide population-based retrospective cohort study were obtained from Taiwan’s National Health Insurance Research Database (NHIRD). All medical conditions for each case and the controls were categorized using the 9th revision of the International Classification of Diseases (ICD-9). Odds ratios and 95% confidence intervals for associations between AF and AA were estimated using Cox regression and adjusted for comorbidities. Results: Our analyses included 116,225 AF cases and 116,225 propensity score-matched controls. Compared with the controls, the patients with AF exhibited a significantly increased risk of developing an AA (adjusted hazard ratio, HR 1.243, p p Conclusion: There are associations between AF and AA. HF is a mutual risk factor for the development of AF and AA.研究目的：心房颤动（Atrial fibrillation, AF）是临床最常见的持续性心律失常。多种与心房颤动发病机制相关的分子通路，同时参与主动脉瘤（aortic aneurysm, AA）的发生与进展过程。本研究旨在评估主动脉瘤与心房颤动之间的潜在关联。 研究对象与方法：本项基于全国人群的回顾性队列研究数据，取自中国台湾地区全民健康保险研究数据库（National Health Insurance Research Database, NHIRD）。所有病例与对照的医疗状况均采用国际疾病分类第9版（International Classification of Diseases 9th revision, ICD-9）进行编码分类。采用Cox回归模型估算心房颤动与主动脉瘤关联的比值比及95%置信区间，并针对合并症进行校正。 研究结果：本分析共纳入116225例心房颤动病例，以及116225例经过倾向得分匹配的对照人群。与对照人群相比，心房颤动患者发生主动脉瘤的风险显著升高（校正后风险比（hazard ratio, HR）=1.243，P<0.001）。 研究结论：心房颤动与主动脉瘤之间存在显著关联；心力衰竭（heart failure, HF）是心房颤动与主动脉瘤发生的共同危险因素。