Activity of chimp neural crest enhancer near FAM222A in E11.5 transgenic mouse embryo - Tg(panTro4_chr12:110112991-110113747::LacZ).

Tg(panTro4_chr12:110112991-110113747::LacZ) chimp neural crest enhancer with reproducible activity in the midbrain, optic cup, facial (VII)/vestibulocochlear (VIII) nerves, and floor plate of the neural tube. This enhancer lacks many of the expression domains associated with the orthologous human enhancer, demonstrating human biased activity when comparing these two species.Tg(panTro4_chr12:110112991-110113747::LacZ) 黑猩猩神经嵴增强子，可在中脑、视杯、面（VII）/前庭蜗（VIII）神经以及神经管底板中呈现可重复的调控活性。该增强子缺失了诸多与直系同源人类增强子相关的表达结构域，跨物种比较时展现出人类偏向性的活性特征。