Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure

Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p心力衰竭（Heart Failure, HF）以伴随能量代谢异常的收缩功能障碍为特征。本研究旨在探究已知可激活能量代谢的多酚类物质白藜芦醇，能否作为心力衰竭的代谢治疗手段发挥获益效应。本研究针对高血压性心力衰竭模型——喂食高盐饮食的Dahl盐敏感大鼠（HS-NT）——评估了生存率、心室与血管功能，以及心肌与骨骼肌的能量代谢情况。在高血压与心肌肥厚形成（于加盐喂养3周后出现）后，对大鼠给予白藜芦醇（18 mg/kg/天，HS-RSV组）持续干预8周。白藜芦醇治疗可提升生存率：HS-RSV组生存率达64%，HS-NT组仅为15%，p