The data presented in Code repository for Kardava, L., Rachmaninoff, N., Lau, W. W., Buckner, C. M., Trihemasava, K., Blazkova, J., ... & Moir, S. (2022). Early human B cell signatures of the prim

Zenodo2022-09-20 更新00

Comprehensive transcriptome characterization deciphers mechanisms underpinning the positive selection of B cells in germinal centers. [mouse; short-read]. Comprehensive transcriptome characterization deciphers mechanisms underpinning the positive selection of B cells in germinal centers. [mouse; short-read]

B细胞免疫应答

转录组可变剪接

Alternative splicing (AS) and translational regulation play major roles in the activation and differentiation of immune cells. Previous studies using short-read sequencing linked individual AS events

NIAID Data Ecosystem00

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

RNA剪接调控

肿瘤免疫治疗

Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could similarly result in ne

NIAID Data Ecosystem30

Next Generation Sequencing analysis of BCR-induced gene expression in adult and neonatal splenic B cells

B细胞免疫应答

发育免疫学

Newborns are unable to reach the adult-level humoral immune response partly due to the potent immunoregulatory role of IL-10. IL-10 expression is controlled by various transcription factors including

NIAID Data Ecosystem00

HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response

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