(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A1 adenosine receptor (A1AR) agonists for CNS or peripheral applications. Human and mo
Clostridioides difficile infection (CDI), a leading cause of antibiotic-associated diarrhea, is driven by the virulence factor toxin B (TcdB), whose receptor-binding interfaces (RBIs) exhibit evolutio
Compounds 1–7 ranked according to potency (in bold) have no activity against additional targets based on polypharmacology records, whereas compounds 8–12 inhibit calcitriol activating enzymes, VDR and
