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Data for: Discovery of Potent Proteolysis Targeting Chimera Degrader of IDO1

NIAID Data Ecosystem2026-03-11 收录

PROTAC药物发现

IDO1靶向降解

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资源简介：

Supplementary Information for Discovery of Potent Proteolysis Targeting Chimera Degrader of IDO1

应用场景：

创建时间：

2020-03-18

肝细胞癌治疗

PROTAC药物发现

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, primarily due to its low immunogenicity and immunosuppressive tumor microenvironment. Inducing immunogenic

NIAID Data Ecosystem90

Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1

靶向蛋白质降解

PROTAC药物发现

Targeted protein degradation induced by heterobifunctional compounds and molecular glues presents an exciting avenue for chemical probe and drug discovery. To date, small-molecule ligands have been di

NIAID Data Ecosystem60

SPR against CypA for macrocycle-based PROTACs targeting cyclophilin A

PROTAC药物发现

蛋白-配体相互作用

SPR binding data for macrocycle-based PROTACs against cyclophilin A

Figshare2024-11-04 更新40

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders

PROTAC药物发现

PRMT5靶向治疗

The aberrant expression of protein arginine methyltransferase 5 (PRMT5) has been associated with multiple cancers. Using the proteolysis targeting chimera technology, we discovered a first-in-class PR

NIAID Data Ecosystem70

PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction

PROTAC药物发现

sEH靶向降解

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme responsible for lipid metabolism and is a promising drug target. Here, we report the first-in-class PROTAC small-molecule degraders of sEH. Our

NIAID Data Ecosystem60

Data for: Discovery of Potent Proteolysis Targeting Chimera Degrader of IDO1

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