Elucidation of biotransformations of N-heterocyclic carbene gold(I) complexes in cancer cells from speciation studies by X-ray absorption sp

Name: Elucidation of biotransformations of N-heterocyclic carbene gold(I) complexes in cancer cells from speciation studies by X-ray absorption sp
Creator: Sorbonne Universite, Institut Parisien de Chimie Moleculaire-IPCM, 4 place Jussieu, 75005 Paris, France; Sorbonne Universite, Institut Parisien de Chimie Moleculaire-IPCM, 4 place Jussieu, 75005, Paris, FRANCE
Published: 2028-01-01T00:00:00+08:00

ESRF Portal2028-01-01 更新2026-04-23 收录

金属药物代谢

癌症机制研究

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https://doi.esrf.fr/10.15151/ESRF-ES-2227965990 数据链接链接失效反馈

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资源简介：

Linear, two-coordinate gold(I) complexes comprising an N-heterocyclic carbene (NHC) ligand and various other coligands have been found to display anticancer properties related to the nature of the ancillary ligand. Since gold(I) compounds are known to act as prodrugs, undergoing activation via ligand(s) exchange, uncovering the still unknown biotransformation pathways sustained by NHC-gold(I) complexes will provide complementary data regarding their mechanism of action. Following previous experiments at the BM16 beamline (exps. LS-3235 and LS-3432), we successfully determined the speciation of biphenyl gold(III) complexes in cancer cells from cryo-X-ray absorption spectroscopy (XAS) measurements. We now apply for beamtime at BM16 in order to investigate the intracellular speciation of 5 different NHC-gold(I) compounds to try and draw a relationship between their structure, biotransformation and cytotoxic activity.

提供机构：

Sorbonne Universite, Institut Parisien de Chimie Moleculaire-IPCM, 4 place Jussieu, 75005 Paris, France; Sorbonne Universite, Institut Parisien de Chimie Moleculaire-IPCM, 4 place Jussieu, 75005, Paris, FRANCE

创建时间：

2028-01-01