Supplementary Material for: The Impact of <b><i>CYP24A1</i></b> Polymorphisms on Hypertension Susceptibility

<b><i>Background:</i></b> Hypertension is one of the leading causes of human death and disability. <i>CYP24A1</i> regulates vitamin D activity and is closely linked to hypertension. However, the relationship between <i>CYP24A1</i>polymorphisms and hypertension risk remains unclear. <b><i>Methods:</i></b> This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of <i>CYP24A1</i>polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of <i>CYP24A1</i>and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models. <b><i>Results:</i></b> We found that rs56229249 of <i>CYP24A1</i>significantly<i></i>decreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29–0.91,<i> p</i> = 0.022) and recessive models (OR 0.51, 95% CI 0.29–0.91,<i> p</i> = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (&lt;61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women. <b><i>Conclusions:</i></b> Our study suggests that genetic variations of the <i>CYP24A1</i>gene were significantly associated with susceptibility to hypertension in the Chinese population.