The top addressed synlet interactions based on sum of PubMed ID (PMID) counts as well as the respective novel proposed drug combinations are given in Table 1. Synlet interactions are sorted in descend

Figshare2019-01-25 更新10

Synthetic lethal screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition. Synthetic lethal screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition

合成致死筛选

ATRX突变癌症靶向治疗

we performed a genome-wide synthetic lethal screen, using CRISPR-Cas9 genome editing, to identify potential therapeutic targets specific for ATRX-mutated cancers. In isogenic hepatocellular carcinoma

NIAID Data Ecosystem30

GO:2001234 (negative regulation of apoptotic signaling pathway)

凋亡信号通路

基因组相互作用

This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.

NIAID Data Ecosystem10

Chlamydomonas mutants used to generate diploids for SSNC screening.

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