Alpha-synuclein supports type 1 interferon signaling in neurons and brain tissue

To investigate broad difference in gene expression in mice wild-type for or knockout for alpha-synuclein during infeciton, we infected mice via footpad infection with West Nile Virus and measured full brain gene expression. comparitive gene expression profiling using data obtained from RNA-seq in two different mouse lines at one timepoint

搜集汇总

背景与挑战

背景概述

该数据集通过RNA-seq技术比较了野生型和α-突触核蛋白敲除小鼠在感染西尼罗病毒后的全脑基因表达差异，旨在探究α-突触核蛋白在神经元和脑组织中对1型干扰素信号通路的支持作用。实验设计包括两种小鼠品系在单一时间点的基因表达比较，为理解α-突触核蛋白的免疫调节功能提供了数据支持。