Purified B cells were costimulated with CpG2006, A/Victoria/361/2011 viruses and IL-15. Stalk-reactive IgG in supernatants was detected at day 6. Chimeric molecules cH5/3, cH4/7 and cH5/1 were used fo
‡Titer unit in Log2. *Comparison of HI and neutralizing antibody titers of seasonal viruses to H1N1pdm on the indicated days pI using Student's t-test, p<0.05.
Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many potent antibodies with broad, intra-subtype
