Survival rates in HSV-2 MS challenge experiments.

aImmunization status of mice at the time of HSV-2 MS challenge, which were vaccinated 45 to 190 days earlier with culture medium (naïve), GFP, gD-2, 0ΔNLS, or HSV-2 MS. bFrequency of mice that survived until 30 days after challenge with wild-type HSV-2 MS. The total number of independent experiments performed is indicated by the n-value in parentheses. *p<0.05 that the survival frequency was equivalent to naïve mice following HSV-2 MS challenge, as determined by Fisher's Exact Test. **p<10−6 that survival frequency was equivalent to naïve mice following HSV-2 MS challenge, as determined by Fisher's Exact Test. ‡p<10−8 that survival frequency was equivalent between mice immunized with HSV-2 0ΔNLS versus a gD-2 subunit vaccine following HSV-2 MS challenge, as determined by Fisher's Exact Test.