Fig 1. Schematic illustration of the two-step test. Participants estimated the two-step distance forward with maximum effort and indicated the distance using a laser pointer. After the estimation, the

DataCite Commons2025-06-01 更新60

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

变构药物开发

神经肌肉疾病治疗

Glycogen synthase kinase 3 β (GSK-3β) is a central target in several unmet diseases. To increase the specificity of GSK-3β inhibitors in chronic treatments, we developed small molecules allowing subtl

NIAID Data Ecosystem40

Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations

神经肌肉疾病治疗

痉挛性截瘫症状管理

ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may impr

Figshare2018-03-01 更新60

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

神经肌肉疾病治疗

组蛋白去乙酰化酶抑制剂

X-linked myotubular myopathy (XLMTM) is a fatal neuromuscular disorder caused by loss of function mutations in MTM1 . At present, there are no directed therapies for XLMTM, and incomplete understandin

NIAID Data Ecosystem50

Motor outcome after surgery or botulinum toxin injection.

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