Grafting of short elastin-like peptides using an electric-field

In this work, we investigate using an electric-field to control surface-grafting of short elastin-like polypeptides (ELPs) for the first time. Specifically, the goal of this study is to test the hypothesis that electric field and ELP composition will impact the ELP grafting density, grafting kinetics, grafted morphology and structural transition properties. In doing so, we uncover specific drivers for ELP assembly that can be used to control ELP surface properties for future use in applications such as sensing, tissue engineering and capture/release applications.本研究首次探索利用电场调控短链类弹性蛋白多肽（elastin-like polypeptides，ELPs）的表面接枝过程。具体而言，本研究旨在验证下述假说：电场与ELP组成会对ELP的接枝密度、接枝动力学、接枝形貌以及结构转变特性产生影响。通过本研究，我们明确了ELP组装的特定驱动机制，该机制可用于调控ELP的表面性质，以应用于传感、组织工程以及捕获/释放等未来应用场景。