Data from: Effects of working-memory training on striatal dopamine release

Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.

工作记忆更新与纹状体-前额叶脑区以及相位性多巴胺神经传递密切相关。本研究在为期5周的工作记忆更新训练前后，分别在字母更新任务与对照条件下，评估了雷氯必利（raclopride）与纹状体多巴胺（DA）D2受体的结合情况。结果显示，训练前的工作记忆更新即可影响多巴胺活动，且经过训练后，更新任务过程中的纹状体多巴胺释放水平进一步提升。上述研究结果凸显了与D2受体活动相关的瞬态神经过程在工作记忆中的关键作用。