Supplementary Material for: A Rare Case of Primary Cutaneous CD4+ small/medium Size T-cell Lymphoproliferative Disorder Responding to Rituximab

Introduction: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare lymphoproliferative disorder (PCS-TCLPD) characterized by a solitary erythematous plaque or nodule on the face, neck, or upper trunk with a favorable outcome. Very rarely multiple plaques or masses may be seen in which precise evaluation should be performed to exclude other primary cutaneous lymphoma. Case presentation: Here we report a rare case of recalcitrant primary cutaneous small/ medium sized CD4+ lymphoproliferative disorder in a 55-year-old male patient who responded well to Rituximab injection but had recurrence after one year from the injections. Conclusion: Aggressive treatment is avoided in solitary lesions of PCS-TCLPD, but multiple lesions with no response to the conventional modalities may need more sophisticated management including Anti CD20 rituximab