Data are mean ± SEM.Mann–Whitney test: *PAbbreviations:NC, normal control rats; CP+V, rats with cisplatin-induced nephrotoxicity treated with vehicle; CP+E, rats with cisplatin-induced nephrotoxicity
This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeate
Clinical use of a major cancer chemotherapeutic agent, cisplatin, is restricted to dose-limiting renal toxicity. A transcriptomic approach enabled us to extract putative molecules including Pleckstrin
*In this study, nephrotoxicity was not defined by the investigators. For the purpose of our study, we considered as nephrotoxicity the number of patients who had ≥1.5 times baseline creatinine serum c