The effect of tumor acidic microenvironment on tumor metastasis. Thus,we performed mRNA-seq and sRNA-seq on A549 cell line cultured with acidic medium(pH 6.6) and normal medium(pH 7.4).
Breast tumors are characterized by inherent heterogeneity but the evolving cellular organization of breast tumors through progression remains poorly understood. Individual clones were tracked by combi
Many tumour types are composed of genetically diverse cells, however little is known of how diversity evolves or the impact diversity has on functional properties. Here, using xenografting and DNA cop
Radiomics involves the study of tumor images to identify quantitative markers explaining cancer heterogeneity. The predominant approach is to extract hundreds to thousands of image features, including
As part of our individualized systems medicine program, personalized treatment options are identified and administered to chemorefractory AML patients based on exome sequencing and ex-vivo drug sensit
