we overexpressed progerin in the C3H10 cell line and performed RNA sequencing analysis. 106 genes were down-regulated and 254 genes were up-regulated in progerin expressed cells with fold change great
RNA-sequencing was performed to gain insight into the mechanism responsible for the apoptosis and cell cycle arrest induced by loss of Mdm2 in p53-null cells. Following CreERT2-mediated deletion of Md