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Safety pharmacology studies.
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创建时间：
2018-08-20
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Data_Sheet_1_An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm.PDF
The formulation of in silico biophysical models generally requires optimization strategies for reproducing experimentally observed phenomena. In electrophysiological modeling, robust nonlinear regress
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Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson’s disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of h
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Moxifloxacin: Cardiovascular Effects of Moxifloxacin in Conscious, Telemetered Beagle Dogs
n=4 chronically-instrumented conscious male Beagle dogs, dosed with Moxifloxacin at 10, 30, 90 mg/kg, p.o., successively (wash-out 48h). No PK phase. Parameters: haemodynamic parameters (SAP, DAP, MAP
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Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential
The fast component of the cardiac transient outward current, IKtof, is blocked by a number of drugs. The major molecular bases of IKtof are Kv4.2/Kv4.3 voltage-gated potassium channels. Drugs with sim
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Sotalol: a cardiovascular safety pharmacology study using radiotelemetry in conscious beagle dogs following oral administration
n=3 chronically-instrumented conscious male Beagle dogs, dosed with Sotalol at 20 mg/kg. No PK phase. Parameters: haemodynamic parameters (SAP, DAP, MAP, HR) and ECG (RR, PR, QRS, QT, QTcF and QTcVdW
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