Mc4r^m1Hubr

The Mc4r mutation was generated by target-selected ENU-driven mutagenesis and high-throughput resequencing of genomic sequences in Crl:Wistar background. The mutation was identified as revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r.<br>ASSOCIATED WITH decreased heart rate; decreased locomotor activity; decreased mean systemic arterial blood pressure; ASSOCIATED WITH Insulin Resistance; obesityMc4r 突变经靶向选择的ENU诱导的诱变以及Crl:Wistar品系中基因组序列的高通量重测序生成。该突变被鉴定为在Mc4r的螺旋8区（K314X）中存在由ENU诱导的提前终止密码子。该突变与心率降低、运动活动减少、平均系统动脉血压降低相关；并与胰岛素抵抗、肥胖相关。