WGBS related files

DNA methylation, as well as histone modifications, is an important regulatory mechanism for altered gene expressions. Our previous study hasshown that <i>B</i><i>ombyx mori</i>cytoplasmic polyhedrosis virus (BmCPV)infection could change the level of trimethylation of lysine 9 of histone 3 (H3K9me3)and acetylation of lysine 9 of histone 3 (H3K9ac), thus regulating the mRNAs expressions in the midgut of silkworm, <i>B</i><i>.</i><i>mori</i>. However, the correlation between genome-scale DNA methylome and transcriptome remains underexplored.<b> </b>In this study, whole genome bisulfite sequencing (WGBS) was performed on the midgut of BmCPV-infected silkworms at 48 h and 96 h post infection, and corresponding midguts of uninfected silkworms. And intersection genes were screened by correlation analysis between differentially methylated regions (DMR)-associated genes and differentially expressed genes (DEGs). Above analysis will contribute to further understanding how BmCPV regulate gene expression through epigenetic modification at the genome-wide level.In this item, DMR bed files and methylation calling related files are uploaded.