3D cyto- and receptor architectonic map of macaque primary motor area 4a

A multimodal analysis of the macaque motor cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal agranular cortex, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 13 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of primary motor area 4a of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.本研究针对猕猴运动皮层开展多模态分析，旨在构建一套整合并调和此前已发表图谱间不一致之处的三维图谱（3D atlas）。本次分析采用可经统计学检验的定量方法，对猕猴额叶无颗粒皮层的细胞构筑学（cytoarchitecture）展开研究，并结合体外（in vitro）定量受体放射自显影技术，对13种不同神经递质受体的区域及层状分布模式进行分析。研究人员将所识别脑区的边界描绘至立体定位空间中的猕猴参考脑模板上。本研究首次提供了猕猴大脑初级运动皮层4a区的图谱，该图谱整合了立体定位空间中的细胞构筑与受体构筑特征。该三维图谱可为非人灵长类动物的功能实验分析提供宝贵资源，同时为基于真实突触动力学的建模研究提供关键数据。