Sequence variation in enhancers, a class of cis-regulatory elements that control cell type-specific gene transcription, contributes significantly to phenotypic variation within human populations. Enha

NIAID Data Ecosystem20

Developmental Competence Encoded at the Level of Enhancers

发育表观遗传学

增强子功能分析

The emergence of distinct cell types during embryonic development relies on the ability of progenitor cells to properly interpret environmental cues; yet how this developmental competence is establish

NIAID Data Ecosystem10

STARR-seq in 1.8 XX and XO mESCs during differentiation

X染色体失活

增强子功能分析

Developmental genes are controlled by complex cis-regulatory landscapes that integrate multiple signals to ensure the correct spatio-temporal expression pattern. To investigate the underlying regulato

NIAID Data Ecosystem30

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks [CrispR_FOXA1]. Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks [CrispR_FOXA1]

膀胱癌表观遗传学

增强子功能分析

RNA-seq Series of Bladder carcinoma cell lines RT112 and SD48 mutated for FOXA1 by CrispR. Overall design: RT112 and SD48 CRispR mutated for FOXA1 and controls.

NIAID Data Ecosystem10

Type1_Fulco_distr_1212_15_4_5_Enhancers

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