Structural models of the human proteome and the identified CRBN binders from Ikaros bonsai library

This dataset contains 2 compressed files: masif_hp_domains.tar.gz includes the structural models of human proteins from AlphaFold DB (v4) we used in the study. These structural models have been preprocessed into structured domains based on the methods described in the manuscript. Process these structures using MaSIF to create the MaSIF human proteome DB. 6h0f_c_b_bonsai_hits.zip includes all the structural models (post-MaSIF-mimicry alignment) of the binders identified in the Ikaros bonsai library. Open these structures together with the chain B of PDB 6H0F to have their predicted binding modes to CRBN in the presence of pomalidomide.