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TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation

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NIAID Data Ecosystem2026-03-11 收录
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We demonstrate that anti-TNF antibody (Adalimumab) inhibited ~80% of highly LPS-induced genes that sub-serve inflammatory signaling and innate immunity in chorio-decidua neutrophils. Overall design: RNAseq of purified blood maternal neutrophils vs. FACS-sorted chorio-decidua neutrophils in a Rhesus model of intrauterine infection/inflammation

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2020-04-28
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