Austrian Crystallographic Diffraction Consortium

The Austrian Crystallographic Diffraction Consortium (ACDC) BAG aims at supporting several macromolecular structural biology groups across Austria (in total 20 research groups at 9 institutions in 4 cities). We employ mainly the technique of X-ray crystallography to characterize macromolecular biological complexes, but also solution scattering approaches are frequently used to characterize dynamic assemblies. Approval of this BAG will be essential for researchers in all our groups to carry out their structural studies on various health-related and basic research-oriented topics, which are targeted at characterizing large molecular assemblies or proteins currently under-represented in the PDB, including membrane proteins. Corresponding high-resolution diffraction data are only obtainable through the use of synchrotron radiation sources. Thus regular synchrotron access is highly desirable to maintain a competitive advantage in our individual research fields.奥地利晶体衍射联盟（Austrian Crystallographic Diffraction Consortium，ACDC）项目组（BAG）旨在支持奥地利境内的多家大分子结构生物学研究团队，涵盖4座城市的9家机构共计20个研究小组。我们主要采用X射线晶体学技术对大分子生物复合物进行结构表征，同时也频繁使用溶液散射技术来解析动态分子组装体的结构。本项目组（BAG）的获批，将是所有团队研究人员开展各类健康相关及基础研究导向课题的结构生物学研究的必要前提，这些课题聚焦于解析目前在蛋白质数据库（Protein Data Bank, PDB）中占比偏低的、包括膜蛋白在内的大型分子组装体或蛋白质的结构。由于此类研究所需的高分辨率衍射数据仅能通过同步辐射光源获取，因此稳定获取同步辐射光源的使用权限，对我们在各自研究领域保持竞争优势至关重要。