aFIC index (MIC50 of drug A in combination)/(MIC50 of drug A alone) + (MIC50 of drug B in combination)/(MIC50 of drug B alone). A FIC of<0.5 is indicative of synergism.

NIAID Data Ecosystem40

Summary thrombolytics

血栓溶解

临床数据

Summary tables (thrombolytics)

DataONE2018-03-30 更新30

CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX

蛋白质晶体

血栓溶解

CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX Descriptor: PLASMINOGEN, STREPTOKINASE, SULFATE ION Authors: Wakeham, N, Terzyan, S, Zhai, P, Loy, J.A, Tang, J, Zhang, X.C. De

Protein Data Bank Japan2024-10-30 更新40

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core. Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

白血病靶向治疗

药物协同效应

We investigated the combination of the irreversible LSD1 inhibitor T-3775440 and the JAK1/JAK2 inhibitor ruxolitinib as novel therapeutic approach in ML-DS which is specifically designed to target key

NIAID Data Ecosystem40

Figure 6 Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK

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