Increased Susceptibility of <i>Dcx</i> KO Mice to PTZ-induced Seizures.

0, no response; 1, myoclonic jerks; 2, clonic seizures associated with trembling and chewing; 3, tonic-clonic seizures associated with extension of fore- and hind limbs with animals falling on its side. Death, which could occur without behavioral seizures, was noted independently of the seizure score. We observed here that whereas the convulsive dose 50 s (CD50s) of 59.13 mg/kg was previously reported in C57BL/6J mice, PTZ at 50 mg/kg i.p. induced death in a large proportion of our KO and WT mice within less than 5 min following injection (C57BL/6N background, exp A). Results obtained for the EEG experiment (D) are shown separately to the data obtained at the same concentration for the behavioral assessment alone (C), to take into account the implantation of the electrodes and the different sites where these experiments were performed.