Zona incerta distributes a broad movement signal that modulates behavior

The zona incerta is a subthalamic nucleus made up mostly of GABAergic neurons. It has wide- ranging inputs and outputs and is believed to have many integrative functions that link sensory stimuli with motor responses to guide behavior. However, its role is not well established perhaps because few studies have measured the activity of zona incerta neurons in behaving animals under different conditions. To record the activity of zona incerta neurons during exploratory and cue-driven goal-directed behaviors, we used electrophysiology in head-fixed mice moving on a spherical treadmill and fiber photometry in freely moving mice. We found two groups of neurons based on their sensitivity to movement, with a minority of neurons responding to whisker stimuli. Furthermore, zona incerta GABAergic neurons robustly code the occurrence of exploratory and goal-directed movements, but not their direction. To understand the function of these activations, we performed genetically targeted lesions and opt..., The details are described in the associated eLife paper. , , # Zona incerta distributes a broad movement signal that modulates behavior The data correspond to the figures and panels shown in the published paper. ## Description of the data and file structure All files are .ogwu books from Originlab. Find the free reader online here: All files are labeled according to the figure, plot, and trace/column color they correspond to in the paper. The books include defining metadata shown as parameter rows or indexed columns. These refer to information related to the plots shown in the paper. Each book contains traces (time series) or measured values as noted below. Any additional data or metadata in the books (not listed below) are not detailed/included in the related paper. ### Fig1C: **Event**: (=) Cxp or (=) Cxp4 **Class2**: type of cell **Site**: site ID ### Fig2AB: **Long Name**: stimulation protocol **Cell**: cell ID **Class1**: type of cell **Class2**: type of cell ### Fig3BC: **File**: filename **Event**: event ID **Variable**...未定带（zona incerta）是一类丘脑下核团，绝大多数由γ-氨基丁酸能神经元（GABAergic neurons）构成。该核团拥有广泛的传入与传出纤维连接，被认为具备多种整合功能，可将感觉刺激与运动反应相联结以调控行为。然而其具体功能尚未被完全阐明，这或许是由于鲜有研究在不同实验条件下，于行为学状态的动物中记录未定带神经元的活动。为记录动物在探索行为与线索驱动的目标导向行为过程中未定带神经元的活动，本研究分别采用两种实验手段：对头部固定并在球形跑步机上运动的小鼠实施电生理记录，以及对自由活动小鼠开展光纤光度法（fiber photometry）检测。研究人员根据神经元对运动的敏感性将其分为两类，其中仅有少数神经元会对触须刺激产生响应。此外，未定带的γ-氨基丁酸能神经元可显著编码探索行为与目标导向运动的发生事件，但无法编码运动方向。为探究此类神经元激活的功能意义，我们开展了基因靶向损毁与光遗传学相关实验，具体细节已在相关eLife论文中详述。 # 未定带传递调控行为的广谱运动信号 本数据集与已发表论文中的图表及子图一一对应。 ## 数据集与文件结构说明 所有文件均为Originlab出品的.ogwu格式工作簿，可通过在线渠道获取免费阅读器。 所有文件均根据其在论文中对应的图表、绘图结果以及轨迹/列颜色进行命名。 此类工作簿包含定义性元数据，以参数行或索引列的形式呈现，对应论文中绘图相关的各类信息。每份工作簿均包含下文所述的轨迹（时间序列）或实测数值。工作簿中未在下文列出的额外数据与元数据，未在相关论文中进行说明。 ### 图1C： **事件**：(=) Cxp 或 (=) Cxp4 **分类2**：细胞类型 **记录位点**：位点ID ### 图2AB： **完整名称**：刺激方案 **细胞**：细胞ID **分类1**：细胞类型 **分类2**：细胞类型 ### 图3BC： **文件**：文件名 **事件**：事件ID **变量**……